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Sabtu, 26 Oktober 2013

‘Fallon’ Wraps Pearl Jam Week With ‘Lightning Bolt’ - ( T3CHNLG1 )

‘Fallon’ Wraps Pearl Jam Week With ‘Lightning Bolt’

Eddie Vedder reminisces about ‘Balls In Your Mouth,’ chats with Javier Bardem

Late Night With Jimmy Fallon wrapped up its weeklong Pearl Jam celebration last night with a second and final visit from the band. After performing their new single “Sirens” the night before, Pearl Jam launched into “Lightning Bolt,” the title track off their new album.

Eddie Vedder sat down with Jimmy Fallon and fondly reminisced about the pair’s 2011 duet, “Balls In Your Mouth.” “It’s really an environmental anthem,” Vedder mused. He also chatted with fellow-guest and Pearl Jam fan Javier Bardem, telling a story about Bardem introducing the band at a concert in Spain that left the audience in tears. “I was drunk,” Bardem explained. “I didn’t know what I said, but apparently people didn’t like it. They were crying for the wrong reasons.”

15 Insanely Great Pearl Jam Songs Only Hardcore Fans Know

Pearl Jam Week on Late Night involved a wide array of treats and surprises, starting with Chris Cornell and the Avett Brothers’ cover of “Footsteps” on Monday. Tuesday saw Fleet Foxes singer Robin Pecknold make his first TV appearance in nearly two years to sing “Corduroy,” and Pearl Jam guitarist Mike McCready joined Dierks Bentley and the Roots for a cover of “Alive” on Wednesday.

Analysis of Herbal Products Shows Contamination Is Common – Science Daily (press release) - ( T3CHNLG1 )

Oct. 10, 2013 — Most herbal products, available to buy as alternative medicines, may be contaminated. Reporting in BioMed Central’s open access journal BMC Medicine researchers demonstrate the presence of contamination and substitution of plant species in a selection of herbal products using DNA barcoding.

There is currently no best practice for identifying plant species in herbal products. Traditionally plants are identified through the appearance of the whole plant. This method is not useful though when analyzing processed plant material. DNA barcoding analyses a short genetic sequence from the plant’s genome and identifies small differences that allows species identification. In this new study the researchers used barcoding to examine the plant species found in a sample of herbal plant products.

The results showed that 59% of the products contained plant species not listed on the labels. Over two thirds of the products tested had plant species present which were a substitution for the plants listed on the label and a third of products also contained other species that may be a filler or contamination.

According to the World Health Organization, the adulteration of herbal products is a threat to consumer safety. In this current analysis the researchers detected plant species that could pose serious health risks when consumed. The results revealed plant species with known toxicity, side effects and/or negatively interact with other herbs, supplements, or medications were present in some products.

The authors concluded that the contamination and substitution dilute the effectiveness of otherwise useful remedies, lowering the perceived value of all related products because of a lack of consumer confidence in them. ‘We suggest that the herbal industry should embrace molecular diagnostic tools such as DNA barcoding for authenticating herbal products through testing of raw materials used in manufacturing products. This would be a minor cost to industry with a limited amount of bulk product testing, which would certify a high quality, authentic product’, said Dr. Steven Newmaster of the University of Guelph and lead author of the paper.

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The above story is based on materials provided by BioMed Central Limited.

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Journal Reference:

Steven G Newmaster, Meghan Grguric, Dhivya Shanmughanandhan, Sathishkumar Ramalingam and Subramanyam Ragupathy. DNA barcoding detects contamination and substitution in North American herbal products. BMC Medicine, October 2013 DOI: 10.1186/1741-7015-11-222

Note: If no author is given, the source is cited instead.

Celgene arthritis drug appears effective, safe after one year: study - ( T3CHNLG1 )

By Bill Berkrot

(Reuters) – Previously untreated patients experienced significant and lasting reductions in signs and symptoms of psoriatic arthritis when given Celgene Corp’s experimental oral drug, apremilast, according to data from a late stage clinical trial.

Patients taking either the 20 milligrams or 30 mg dose of apremilast twice a day had a statistically significant improvement in symptoms, such as painful, swollen joints, after 16 weeks of treatment compared with those who received a placebo, researchers said.

Signs and symptoms of the painful disease continued to improve on apremilast through a year of treatment, according to data to be presented next week at the American College of Rheumatology meeting in San Diego.

If approved, apremilast will compete with injected biotech medicines that have proved to be highly effective, but have more serious potential side effects, such as opportunistic infections and tuberculosis because the biologics suppress the immune system.

“Psoriatic arthritis can be one of the most crippling types of arthritis that we see,” said Dr. Alvin Wells, the lead investigator of the 527-patient study who will present the data at the ACR meeting on Tuesday.

“To be able to have a patient that can take a pill twice a day, I think this is going to be a game changer, not only for me as a physician, but for my patients. They’re going to have a new treatment option,” added Wells, director of the Rheumatology and Immunotherapy Center in Franklin, Wisconsin.

The U.S. Food and Drug Administration is expected to make an decision on the drug in March.

Celgene has said sales of apremilast could reach $ 1.5 billion by 2017. Wall Street analysts’ projections have been more modest, with RBC Capital Markets forecasting sales of $ 1 billion in 2017, while Cowen and Co sees annual sales reaching $ 475 million in 2018.

The primary goal of the study dubbed Palace 4 was a 20 percent reduction in signs and symptoms of the disease, known as ACR20, after 16 weeks versus placebo.

At that point, 29.2 percent of those who got the 20 mg dose and 32.3 percent to took 30 mg achieved ACR 20, compared with 16.9 percent on placebo.

After 52 weeks on the drug, 53.4 percent on the lower dose and 58.7 percent on the higher dose achieved an ACR20 response.

“These patients are on drug a long time so I want to see that it’s going to last,” said Wells, calling the results “a pretty dramatic response.”

Placebo patients who did not respond early in the trial were switched to apremilast. By week 24 there were no longer any patients receiving placebo, Wells explained.

Researchers also looked at how many patients experienced improvements of 50 percent and 70 percent.

At 52 weeks, for those on the higher dose of apremilast, 31.9 percent had achieved ACR50 and 18.1 percent ACR70, researchers said.

About 125 million people worldwide suffer from the scaly skin condition psoriasis and about 30 percent of them can develop psoriatic arthritis, a chronic, progressive disease in which joints become swollen and inflamed.

Apremilast is the first drug in a new class of medicine called PDE4 inhibitors.

“It inhibits an enzyme involved in making all these angry proteins that get into the skin, causing psoriasis, and they also get into the joints, causing arthritis,” Wells said.

The most common side effects with apremilast were diarrhea, nausea and headache. No more serious adverse side effects were reported, and fewer than 2 percent of patients in the study discontinued treatment due to side effects.

(Reporting by Bill Berkrot. Editing by Andre Grenon)

CVS deals 10/27: Herbal Essences, 7UP, Coke, candy & more! – WRAL.com - ( T3CHNLG1 )

Posted: 9:45 p.m. yesterday

CVS has some good buys starting on Sunday including Herbal Essences, 7UP, Coke, Pampers, Gold Emblem spices, candy & more!

The CVS coupon policy can be found on their website at cvs.com

Reminder: Check your CVS coupons from the coupon kiosks for the last couple weeks to see if you have any to go with the deals below.

Double Quarterly Extrabucks! CVS is offering Double Quarterly Extrabucks from September 16 – December 15 for in-store and online purchases when you sign up! The DOUBLE Quarterly ExtraBucks Rewards will be available on CVS.com, at the bottom of your in-store receipt or at the ExtraCare Coupon Center starting 1/1/14.
You can sign up for the double rewards promotion on the CVS website. For more information on the Quarterly Extrabucks, click the link in the box above.

These deals are valid 10/27 – 11/2

Gift Card deal: Spend $ 30 on iTunes or App Store gift cards and get a $ 5 Extrabucks reward

Food

Arizona drinks, 23 – 23.5 oz, 2 for $ 1, limit 10

Campbell’s tomato or chicken soup, 10.75 oz, .75 – .40/4 coupon from 10/6 SS = .65 each when you buy 4

7UP, A&W, Canada Dry, Sunkist, 2 ltr bottle, .99 – .30 coupon from in-store coupon kiosk = .69, limit 1 with coupon, limit 5 at .99

Gold Emblem spices, .88

Bumble Bee chunk light tuna, 5 oz can, .88

Coke, 2 ltrs, .99, Limit 5

Chex Mix or Gardettos snack mix, 2 for $ 3 – .50/2 Chex coupon from 9/29 SS, possible .50/2 coupon from 10/27 SS = $ 1.25 each

Gold Emblem crackers, 6.6 – 7.5 oz, 3 for $ 5

Coke 12 packs, 4 for $ 9.9, limit 4 of the 12 packs – good deal (must buy 4 at same time to get deal)

7UP, Canada Dry, A&W, Sunkist 12 oz cans, 12 pack, 3 for $ 11 – $ 3 +UP when you buy 3 = 3 for $ 8 ($ 2.66 each)

Candy

Starburst, Jolly Rancher, Junior mints, Charleston Chew, Tootsie, Skittles, Blow Pop, Dum Dums, Whoppers, Milk Duds, 8.67 – 12 oz: 2 for $ 4 – $ 1 Extrabucks reward when you buy 2, Coupons include $ 1.50/2 Jolly Rancher coupon from Smart Shopper coupons above link recently, .75/1 Starburst and Skittles coupon from 8/25 RP

Gold Emblem Candy pumpkins, candy corn, autumn mix, 7.5 – 9 oz, .88

Twizzlers Twists 22 oz or Hershey’s snack size, Nestle, Mars chocolate fun size candy 9.78 – 12 oz
Sale: $ 1.88
Coupons: $ 1/2 Twizzlers coupon from 10/13 SS, $ 1.50/2 Twizzlers coupon from Smart Shopper coupons link above recently, $ 1.50/3 Hershey’s coupon from 10/20 SS, Nestle candy coupon from 10/13 RP, $ 1.50/3 Mars coupons from 10/6 and 9/15 RP
Total after $ 1.50/2 coupon = $ 1.13 each – good deal
Total after $ 1/2 coupon or $ 1.50/3 coupon = $ 1.38 each – still a decent deal

Hershey’s kisses or miniatures, 10 – 15 oz
Sale: 5 for $ 15
Extrabucks: $ 5 reward when you buy 5

50% off Halloween costumes

Non-Food

Dawn dish soap, 9 oz, .99 – .25/1 coupon from 10/27 & 9/29 (exp 10/31)

VO5 shampoo or conditioner, .82

Puffs, .99 – .25/3 coupons from 10/27 & 9/29 (exp 10/31)

Herbal Essences or Aussie shampoo, conditioner or styler
Sale: 2 for $ 6
Extrabucks: $ 1 reward on 2
Coupon: $ 3/2 coupon from 9/15 SS, $ 1/2 coupon from 10/6 RP
Total after $ 3/2 coupon and reward = 2 for $ 2 ($ 1 each)

Nivea lip care, 2 for $ 5 – possible $ 3/2 coupon from 10/27 RP = 2 for $ 2

Pantene shampoo, conditioner or styler
Sale: 3 for $ 10
Extrabucks: $ 1 reward when you buy 3
Coupon: BOGO coupon from 9/15 SS (exp 10/31), $ 3/2 coupon from 9/29 PG, various possible coupons from 10/27 PG, $ 1 styler coupon from Smart Shopper coupons link recently

Oral-B manual toothbrush, 1 count
Sale: $ 2.87
Extrabucks: $ 1 reward, limit 2
Coupon: .50/1 coupon from 9/29 PG, possible .50 from 10/27 PG
Total after coupon and reward = $ 1.37 (my buy price is 50 cents or less for a toothbrush after coupons and rewards)

Colgate battery powered toothbrush, 1 count
Sale: $ 5.99
Extrabucks: $ 2.00, limit 2
Coupon: possible $ 2 coupon from 10/27 SS
Total after coupon and reward = $ 1.99

Listerine, various, 1 ltr, Total Care, Ultraclean 500 ml, Reach floss
Sale: $ 3.99
Extrabucks: $ 1.00, limit 2
Coupon: .50 Listerine coupon and $ 1 Reach floss coupon from 10/6 SS
Total after $ 1 coupon and reward = $ 1.99 (my buy price for floss is .50 or less after rewards and coupon)

Gillette Venus Razor or ProGlide razor, 1 count
Sale: as low as $ 6.99 online for Venus razor
Extrabucks: $ 5.00, limit 1
Coupon: $ 2 Venus coupon from 9/8 RP (exp 10/31), $ 3 ProGlide from 9/29 PG (exp 10/31), possible coupons from 10/27 PG

Tide detergent, 19 – 32 loads
Sale: $ 5.94
Extrabucks: $ 1 reward, limit 1
Coupon: $ 2 coupon from 9/29 PG (exp 10/31), possible $ 2 coupon from 10/27 PG
Total after reward and coupon = $ 2.94 (Good price for Tide but my buy price is $ 2 or less for 50 oz laundry detergent. If you only buy Tide, this is a very good price for this brand.)

Pampers jumbo packs
Sale: $ 8.99
Extrabucks: $ 1.00, limit 1
Coupons: $ 2/2 coupon from 9/29 PG (exp 10/31), various $ 1.50 coupons from Smart Shopper coupons link recently, possible coupon from 10/27 PG insert
Total after $ 1.50 coupon and reward = $ 6.49

CVS multiples, letter vitamins, and other various supplements, BOGO, limit 8

CVS Protective Undergarments, BOGO

$ 4 off $ 12 Cosmetics coupon from in-store coupon kiosk

Turn to herbal relief to help ease chronic nerve pain – Tulsa World - ( T3CHNLG1 )

Dear Pharmacist, I have nerve pain that is chronic and related to my diabetes. I take medication for that, and want to add some supplements that might help. I promise to ask my doctor if they’re alright for me. — P.T., Tulsa

Nerve pain is termed “neuropathy,” and sometimes you see it as “peripheral neuropathy.” It can be described as tingling, burning, radiating and sharp. Everyone’s experience is different.

Diabetes medications can sometimes exacerbate neuropathy by causing a drug nutrient depletion. Some of the most popular medications prescribed (e.g. metformin, glipizide) are “drug muggers” of vitamin B12. You need B12 to produce myelin, a protective fatty coating around your nerve fibers. Your nerves get touchy and neuropathy can begin if you run out of myelin. Supplementing with methylcobalamin might help, but do test to see if you are low in that. It’s a blood test. There is more about nerve-soothing remedies in my “Diabetes Without Drugs” book.

Herbs that are in the “nervine” category can be very nourishing and soothing to the nerve tissue. Among the best are Chinese skullcap, lemon balm, wood betony, St. John’s wort, chamomile, prickly ash and milky oats. These are found in a variety of ways including commercial tea, dried herb so you can make your own tea or compress, tinctures, capsules and so forth. They each have a book full of side effects and precautions. Do not take it upon yourself to just self-treat without seeing a knowledgable practitioner who studies and prescribes herbs for a living.

For milder effects you could always take a bath in herbs; mix together the following to make two cupfuls: oatstraw, skullcap, wood betony and St. John’s wort. Put it in a clean sock and drop into your bath. You can also add five to 10 drops of lavender essential oil. Soak for at least 20 minutes, keeping the water lukewarm. This must be discussed with your practitioner as there is transdermal absorption of these herbs. If you have a local (small) area, you can also try a commercial product called Neuragen sold at pharmacies nationwide.

For more, visit dearpharmacist.com.

Quincy Jones Sues Michael Jackson Estate - ( T3CHNLG1 )

Producer claims breach of contract, seeks millions in damages and unpaid royalties

Quincy Jones filed a lawsuit against Michael Jackson’s estate on Friday, seeking millions of dollars in royalties over projects that were released after the singer’s death. The legendary producer is claiming that the way Jackson’s work was used in the This Is It film and soundtrack album, as well as the Michael Jackson Cirque du Soleil productions and the 25th anniversary edition of Bad, involve a breach of contract. Jones also included Sony Music Entertainment, the parent company of Jackson’s label, Epic Records, in the suit.

According to The Hollywood Reporter, the producer claims that master recordings of songs he worked on were remixed and edited in order to deprive him of profits that he would have been entitled to under agreements he signed with Jackson in the 1970s and 1980s. He says that under the contracts, he should have been given the first opportunity to re-edit or re-mix any of the master recordings and that he was entitled to producer credit for the master recordings, as well as additional compensation if the masters were remixed.

See Where Michael Jackson Ranks on Our List of the 100 Greatest Artists

Jones produced three huge solo albums for Jackson: 1979′s Off the Wall, 1982′s Thriller and 1987′s Bad. Following the singer’s 2009 death from an overdose of the anesthetic propofol, Columbia Pictures released the film This Is It, which documented Jackson’s preparations for his concert tour. The film and soundtrack featured songs including “Don’t Stop ‘Til You Get Enough,” “Thriller,” “Beat It” and “Billy Jean.” Cirque du Soleil then used a similar array of classic Jackson hits in its 2011 production Michael Jackson: The Immortal Tour and this year’s Michael Jackson: One.

Jones is seeking at least $ 10 million in damages for breach of contract, as well as unpaid royalties, remixing fees and compensation for the loss of credit. “Quincy has been frustrated with these matters for a number of years, felt he was not making any progress and needed to take more formal action,” Henry Gradstein, Jones’ attorney, told THR.

Howard Weitzman, a lawyer for the Jackson estate, issued a statement in response. “The estate of Michael Jackson was saddened to learn that Quincy Jones has filed a lawsuit seeking money from Michael’s estate,” the statement said. “To the best of our knowledge, Mr. Jones has been appropriately compensated over approximately 35 years for his work with Michael.”

Elvis Costello Named Honorary Doctor of Music - ( T3CHNLG1 )

Singer tells New England Conservatory audience that he wrote new songs with Bacharach, may release McCartney demos

As if he hadn’t already proved it countless times with his surgically precise songwriting and the healing power of his gift for melody, Elvis Costello can now call himself a doctor of music. On Friday, the ever-restless musician was on hand in Boston to receive an honorary degree from the New England Conservatory, joining a small, illustrious group – Miles Davis, Aretha Franklin and Quincy Jones – of Rock and Roll Hall of Famers who have been honored by the country’s oldest independent school of music.

15 Rock & Roll Rebels

After accepting his diploma, Costello joked that it was appropriate coming from the New England Conservatory: the old England has tried to kick him out from time to time.

Relaxed and witty as ever, the singer sat onstage for a 90-minute retrospective of his career at the college’s historic, acoustically pristine Jordan Hall, backdropped by the venue’s huge pipe organ. Listening to a snippet of “God Give Me Strength,” his elegant 1996 collaboration with Burt Bacharach, he told the audience that he recently wrote 12 new songs “on a little upright piano” with the 85-year-old pop composer.

He also told his interviewer, Boston Globe critic Sarah Rodman, that he expects to someday release all the demos from his periodic collaborations with Paul McCartney. Asked if he ever stopped to marvel at the fact that he was writing songs with a Beatle, Costello noted that he joined the Beatles’ fan club when he was 11 and joked, “Yeah – what are you, crazy?”

The discussion ranged from his youthful nagging of mentor Nick Lowe to his work with the Brodsky Quartet (with whom he plans a performance to mark the 25th anniversary of the 1993 album The Juliet Letters) and his latest album, with the Roots, Wise Up Ghost. Reminded that his bittersweet lost-love song “Alison” is sometimes played at weddings, he said, “It does seem like an odd choice, doesn’t it?” (One well-known actress once told him she thought of his deeply psychotic dirge “I Want You” as the most romantic song in the world, he said.)

Acknowledging McCartney’s insatiable curiosity and his own, he said he believes that’s the proper way to approach music: “Have all the experiences, not just one.”

“Not everything you write is supposed to be on American Bandstand,” said the singer, who wore a denim jacket, a vest and his trademark porkpie hat for the occasion. At one point, he held up an iPod and commented on the pros and cons of new technology. You can carry around the complete works of Ralph Vaughan Williams in your pocket, he noted; in the old days, “imagine how big your trousers had to be to do that.”

Costello also spoke at length about being a third-generation musician. His father, Ross MacManus, was a singer for hire who sang the popular songs of the day. By the Sixties, Costello said, he’d gone “a little paisley around the edges.”

What if Costello’s father had been, say, a milkman rather than a musician? Rodman asked. “My mother would have some explaining to do,” he joked in reply. He also revealed how he learned only recently that his mother, Lilian, was involved in “a minor smuggling ring.” With recordings scarce in England after World War II, she arranged for merchant mariners to bring back jazz records from the U.S. for her clients.

After taking a few questions from the audience, Costello headed to the airport to fly to San Francisco, where he will appear with his wife, Diana Krall, this weekend at Neil Young’s annual Bridge School concert. On Monday, Costello will be on The Tonight Show to help celebrate the release of longtime keyboardist Steve Nieve’s new duets album, ToGetHer.

“The longer it goes on,” he said about Nieve, “the more incredible it becomes to me the adventures we’ve had together.”